Prolonged Post-Surgical Pain in or around a Healed Wound/Scar?
Posted by 'PeteMoore' Thu, January 10, 2019
An exciting study is now well underway at St Pancras Clinical Research looking at a new treatment to relieve prolonged pain in or around a healed scar following thoracic or abdominal surgery ie on the torso. The staff at St Pancras Clinical Research are specialists experienced in treating and researching painful conditions.
Ipsen, a major French pharmaceutical company, has launched this study with St Pancras Clinical Research in London for patients experiencing long-term pain in or around a scar, long after the original surgical wound and the scar itself has healed.
What does the trial involve?
This study is made up of two parts:
Initially, we do some tests to confirm that there might be the potential to benefit from the new locally administered treatment. This is done by comparing the pain relief after injections, one week apart, of local anaesthetic (lidocaine) with placebo (sham). Pain perception (rated on a scale of 0-10) is assessed up to 24-hours after each injection. Participants who ‘respond’ at this point - meaning that they experience appreciable pain relief from the local anaesthetic- will progress to the second part of the study.
In the second part of the study, three quarters of these ‘responder’ participants will be randomised to receive either the new treatment, and one quarter will receive the placebo treatment. The placebo contains no active substances but will look and be administrated in exactly in the same way as the active treatment. This is a ‘double-blind trial’, meaning that neither subjects nor the study doctor will know who receives the placebo and who the active treatment. Prior to administering the treatment, we will perform some baseline pain measurements, and train subjects in how to use a wearable ‘Actiwatch’, which records their pain level rating over the next 16 weeks.
Who can take part?
All visits would take place at St Pancras Clinical Research’s clinic in central London a few minutes walk from King’s Cross Station. Reasonable travel costs will be reimbursed, and subjects who complete the trial will also receive £700 to compensate for their time.
To take part, subjects would need to be between the ages of 18-75 and to have had surgery on the torso region involving a thoracic (chest) or abdominal (stomach) wound scar. There must be persistent (every day) pain in or around the scar and the surgery should have taken place no longer than 10 years ago.
Find out more:
To find out more about taking part and/or to register your interest in this study, please click here
We are also conducting other studies for chronic pain conditions such as Complex Regional Pain Syndrome, as well as studies for memory loss (Alzheimer’s Disease and Mild Cognitive Impairment ‘MCI’), so please have a look at the patient website for more information, please click here for more information